Certified Clinical Research Professional Exam Prep
Free practice questions

Free CCRP Practice Questions

10 exam-style questions with answers and explanations, straight from our 1,030-question bank. Tap an answer to check yourself. When you're ready, take the scored version in the free practice test.

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These 10 free CCRP questions are organized by exam domain, so you can see how each part of the Certified Clinical Research Professional blueprint is tested. Reveal the answer and explanation under each question.

Domain 1: Research Study Start-Up 40% of exam

Question 1

A 72-year-old woman with longstanding hypertension enters rehabilitation after hospitalization for pulmonary congestion. Echocardiography shows a left ventricular ejection fraction of 58%, concentric hypertrophy, elevated filling pressures, and no significant valve disease. She asks how she could have heart failure when her ejection fraction is preserved. The finding that explains this apparent contradiction is:

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Correct answer: A - Reduced left ventricular compliance, increasing pressure during diastolic filling

Domain 2: Research Study Implementation 50% of exam

Question 2

To 'eat low fat,' a patient with coronary disease replaced cheese and pastries with large portions of fat-free cookies and refined-grain crackers. Weight is unchanged, triglycerides have risen, and LDL cholesterol remains elevated. The dietitian is helping the patient improve food quality without increasing calories. Which substitution best advances that goal?

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Correct answer: B - Replace the refined-grain snack with an equal-calorie portion of unsalted nuts.

Domain 3: Research Study Closure 10% of exam

Question 3

Four months after a myocardial infarction, a 79-year-old participant has unintentionally lost 8% of body weight. BMI remains 28 kg/m², but appetite is poor and rising from a chair has become difficult. The participant is euvolemic, with no recent diuretic change. The team is evaluating the cause of the weight loss. Which weight-management goal is appropriate during that evaluation?

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Correct answer: C - Prevent further unintended loss while restoring nutritional intake and preserving muscle function.

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Question 4

An exercise prescription specifies 60% of heart-rate reserve. The patient's resting heart rate is 60 beats/min on the current metoprolol dose. A recent symptom-limited test on that dose reached 140 beats/min without ischemia or significant arrhythmia; an older test without metoprolol reached 160 beats/min. Which training heart rate implements the prescription using the appropriate test?

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Correct answer: C - 108 beats/min

Question 5

During cycling, an insulin-treated participant becomes shaky and sweaty. Exercise is stopped. The continuous glucose monitor displays 105 mg/dL, but a promptly obtained finger-stick glucose is 58 mg/dL. The participant is alert and can swallow safely. Oral glucose is immediately available. What treatment should be given now?

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Correct answer: D - Give 15 g oral glucose, then recheck the finger-stick level in 15 minutes.

Question 6

At intake, an asymptomatic participant has a blood pressure of 166/94 mmHg after five minutes of seated rest. Recent home readings are approximately 128/78 mmHg. The participant's upper-arm circumference is 40 cm, but the cuff used in the clinic is labeled for arms measuring 22-32 cm. Before interpreting the discrepancy, the rehabilitation professional should:

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Correct answer: B - Repeat the measurement with a validated device and an appropriately sized cuff.

Question 7

An intake PHQ-9 total is 16, with a score of 0 on the self-harm item. In a follow-up interview, the patient reports that low mood and poor motivation interfere with daily activities but denies suicidal thoughts or intent. Which interpretation belongs in the assessment?

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Correct answer: D - Depressive symptoms are moderately severe; further clinical evaluation is needed to determine diagnosis and treatment.

Question 8

A monitored participant suddenly develops a regular monomorphic wide-complex tachycardia at 182 beats/min. A pulse remains palpable, but blood pressure is 76/46 mmHg and the participant becomes confused. Exercise has stopped, the emergency response team is present, and the defibrillator can synchronize reliably. Which intervention should the rehabilitation team prepare to support immediately?

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Correct answer: A - Prompt synchronized cardioversion

Question 9

A warehouse employee wants to resume repeated lifting tasks estimated to require 6 METs. The Duke Activity Status Index suggests a capacity of approximately 7.5 METs. However, a recent adequately performed symptom-limited exercise test ended at 5 METs because of limiting dyspnea. How should the rehabilitation professional use these findings in return-to-work counseling?

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Correct answer: C - Use the demonstrated limitation to guide graded duties and evaluation of the actual lifting tasks.

Question 10

A fasting laboratory report lists total cholesterol 236 mg/dL, HDL cholesterol 36 mg/dL, triglycerides 460 mg/dL, and LDL cholesterol 108 mg/dL. The report identifies LDL as calculated with the Friedewald equation. Before this LDL result is used to judge treatment response, which statement is most important?

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Correct answer: D - The triglyceride level makes this Friedewald estimate unreliable for judging the LDL response.

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